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KMID : 0858420070090020124
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Korean Journal of Stroke
2007 Volume.9 No. 2 p.124 ~ p.127
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Interleukin 6 Level Change in Acute Ischemic Stroke
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Bae Jong-Seok
Kim Sang-Jin
Kim Eung-Gyu
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Abstract
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Background: Cytokines lead to the production of other proinflammatory cytokines including interleukin (IL)-1 and tumor necrosis factor (TNF)-α, which leads to the later production of IL-6 and IL-8. Therefore, we conducted a prospective study to determine the clinical significance of IL-6 levels in acute ischemic stroke.
Methods: We prospectively collected consecutive patients with ischemic stroke patients whose symptom started within 24 hours after symptom onset. Patients with an inflammatory central nervous system diseases, cancer intracranial bleeding, concurrent major cardiac, hepatic, or renal diseases, and cancer patients were excluded. We enrolled people without vascular risk factors (hypertension, diabetes mellitus, hyperlipidemia and nonsmoker) and normal brain MRI (normal group), and Patients with vascular risk factors and abnormal angiography more than 50% of stenosis whose symptoms were developed 30 days prior to blood sampling (atherosclerosis group) as control group. IL-6 was checked on admission, day 1, and 5. If the symptom was progressed, we checked 2 times more (just after progression and 12 hours later).
Results: Fifty six patients were included with 42 men and 14 women. The peak level of IL-6 was detected in the patients with or without progression of symptom on day 1. The level of IL-6 was higher in the patient group compared with the atherosclerosis (P<0.05) and normal groups (on admission and day 1; P<0.05, on day 5; P<0.01). Those Patients with progressed symptoms compared with those without progressed symptoms, the level of IL-6 was higher on day 5 (P<0.001). The level of IL-6 was higher in both large artery disease and cardiogenic embolism groups compared with the lacunar infarction group. The lesion size was correlated with level of IL-6 especially when checked at the time of admission and on day 1, but it did not correlated with on day 5. National Institute of Health Stroke Scale scores did not correlate with the level of IL-6.
Conclusion: Inflammation is involved in those patients with acute ischemic stroke and may play an important role in the progression of symptom. Focusing on anti-inflammatory strategies may be helpful for acute period of ischemia, especially for progressive symptoms. (Korean J Stroke 2007;9:124-127)
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KEYWORD
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Interleukin-6, Acute Ischemic Stroke, Cytokine
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